7. Klinische Anwendung

The increased excretion<665> or reduction of blood or plasma levels are usually used for assessing the clinical efficacy for chelating agents. It would, however, be more important to take into account the reduced burden of critical target organs and recovery from pathological changes. Thus, the organs can be emptied without any change in the blood level. The danger of redistribution of the heavy metal in critical organs (e.g. brain), which has been demonstrated for other chelating agents but not for DMPS<56,417>, must also be taken into account<469>.